Research
Computational metagenomics (tools developed)
- Bacteria-viruses intereaction via CRISPR systems
- Integron (studies of the dynamics and evolution of integron systems)
- Metagenomic sequence binning
- Pathway reconstruction for metagenomes
- Species diversity analysis
- Functional annotation for metagenomics
- ORF(ome) assembly
Protein sequence-structure-function relationship
- Protein structure prediction
- Methodology development
- Apply to human disease related proteins
- Comparison of protein structures
- FATCAT (pairwise comparison allowing structural flexibility) (FATCAT server)
- POSA (multiple structure alignments using partial order graph representation) (POSA server)
- Protein design
- Tool development
- Applications: e.g., design specific inhibitors by interface redesign
Biological network
- Protein domain organization analysis (Fig 1); go to CADO server for details
- Biochemical pathway analysis
- Pathway variant detection (Fig 2)
Fig 1. Domain combination comparison by CADO
Fig 2. Pathway variant detection