Genomics for non-biologists (3 CR)


L504 (Genome Biology for Physical Scientists), Fall 2008
Instructor: Yuzhen Ye, School of Informatics, Indiana University, Bloomington
Contact: yye@indiana.edu
Class meets: 01:00P-02:15P TR I105 (Informatics building)
Office hour: by appointment


  • Topics & schedule

     

    WeekDateDayTopicsSuggested ReadingNotes
    Week 1
    9/2 Tues Overview: From organism to cell to genome Chapter 1 (part I) and 9 Lecture slides

    9/4 Thur The tree of life Chapter 1 (part II) Lecture slides
    Pace paper
    Week 2
    9/9 Tues Cell chemistry
    Homework 1
    Paper reading 1 (paper link)
    Chapter 2 (part I) Lecture slides

    9/11 Thur Proteins: sequence, and structure Chapter 3 Lecture slides
    Week 3
    9/16 Tues Protein function Chapter 3 Lecture slides

    9/18 Thur Metabolism and regulation Chapter 2 (part II and III) Lecture slides
    Week 4
    9/23 Tues Working with proteins (purification & characterization)
    Homework 2
    Paper reading 2 (paper link)
    Chapter 8
    Lecture slides

    9/25 Thur Basics of genetics Chapter 4 Lecture slides
    Week 5
    9/30 Tues DNA, chromosomes and genomes Chapter 4 Lecture slides
    Paper of Bacterial Nucleoid Organization

    10/2 Thur DNA replication Chapter 5 Lecture slides
    Week 6
    10/7 Tues DNA repair and recombination Homework 3
    Paper reading 3 (paper link)
    Chapter 5 (part 5) Lecture slides

    10/9 Thur Transcription (DNA to RNA) and RNA processing Chapter 6 Lecture slides
    Week 7
    10/14 Tues Translation (RNA to protein) Chapter 6 Lecture slides

    10/16 Thur Translation (II) Chapter 6
    Week 8
    10/21 Tues Gene control (I)
    Homework 4
    Paper reading 4 (paper link)
    Chapter 7 Lecture slides

    10/23 Thur Gene control (II) Chapter 7
    Week 9
    10/28 Tues Working with DNA (PCR, sequencing, cloning) Chapter 8 Lecture slides

    10/30 Thur Working with DNA (gene expression and function) Chapter 8
    Week 10
    11/4 Tues MIDTERM

    11/6 Thur Topic 1: Genome projects Lecture slides
    Week 11
    11/11 Tues Membrane structure
    Homework 5
    Paper reading 5 (paper link)
    Chapter 10 & 11 Lecture slides

    11/13 Thur Intracellular compartments and protein sorting (I) Chapter 12 Lecture slides
    Week 12
    11/18 Tues Intracellular compartments and protein sorting (II)

    11/20 Thur Cell communication and signaling pathways Chapter 15 Lecture slides
    Week 13
    11/25 Tues No lecture

    11/27 Thur Thanksgiving
    Week 14
    12/2 Tues The cell cycle & apoptosis

    Paper reading 6 (paper link; PDF file)
    A summary of the paper is required.
    Due in a week
    Chapter 17 & 18 Lecture slides

    12/4 Thur The development of multicellular organisms Chapter 22 & 23 Lecture slides
    Week 15
    12/9 Tues Cancer Chapter 20 Lecture slides

    12/11 Thur Pathogens and the immune system Chapter 24 & 25 Lecture slides
    Week 16
    12/16 Tues FINAL

    Bioinformatics program at IUB